1 Department of Anesthesia, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada Toronto General Hospital Research Institute, Toronto, Ontario, Canada Department of Anesthesia, University of Toronto, Toronto, Ontario, Canada Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada Department of Anesthesia, University of Toronto, Toronto, Ontario, Canada Department of Anesthesia and Pain Medicine, Toronto General Hospital (University Health Network), Toronto, Ontario, Canada Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada, angela.jerath@mail.utoronto.ca.