The target therapeutic effect of functionalized graphene oxide nanoparticles graphene oxide-polyethylene glycol-folic acid-1-pyrenemethylamine hydrochloride-mediated RNA interference of HIF-1α gene in human pancreatic cancer cells

J Biomater Appl. 2019 Aug;34(2):155-177. doi: 10.1177/0885328219847019. Epub 2019 May 12.
No abstract available

Keywords: Hypoxia-inducible factor 1-alpha; RNA interference; deoxyglucose; functionalized graphene oxide; pancreatic cancer.

Publication types

  • Research Support, Non-U.S. Gov't
  • Retracted Publication

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Drug Carriers / chemistry
  • Drug Carriers / metabolism
  • Fluorodeoxyglucose F18 / metabolism
  • Folic Acid / chemistry*
  • Gene Knockdown Techniques
  • Genetic Therapy
  • Glucose Transporter Type 1 / genetics
  • Glucose Transporter Type 1 / metabolism
  • Graphite / chemistry*
  • Humans
  • Hypoxia-Inducible Factor 1, alpha Subunit / genetics*
  • Hypoxia-Inducible Factor 1, alpha Subunit / metabolism
  • Methylamines / chemistry*
  • Mice, Nude
  • Molecular Targeted Therapy
  • Nanoparticles / chemistry*
  • Nanoparticles / metabolism
  • Neoplasms, Experimental
  • Pancreatic Neoplasms / therapy*
  • Polyethylene Glycols / chemistry*
  • Pyrenes / chemistry*
  • RNA Interference / drug effects
  • RNA, Messenger / drug effects
  • Transfection

Substances

  • 1-pyrenemethylamine
  • Drug Carriers
  • Glucose Transporter Type 1
  • HIF1A protein, human
  • Hypoxia-Inducible Factor 1, alpha Subunit
  • Methylamines
  • Pyrenes
  • RNA, Messenger
  • graphene oxide
  • Fluorodeoxyglucose F18
  • Polyethylene Glycols
  • Graphite
  • Folic Acid