Abstract
Diabetic retinopathy is a prevailing diabetes complication, and one of the leading causes of blindness worldwide. IL-17A is a cytokine involved in the onset of diabetic complications. In the current study, we examined the role of IL-17A in the development of retinal inflammation and long-term vascular pathology in diabetic mice. We found IL-17A expressing T cells and neutrophils in the retinal vasculature. Further, the IL-17A receptor was expressed on Muller glia, retinal endothelial cells, and photoreceptors. Finally, diabetes-mediated retinal inflammation, oxidative stress, and vascular leakage were all significantly lower in IL-17A-/- mice. These are all clinically meaningful abnormalities that characterize the onset of diabetic retinopathy.
Keywords:
Diabetic retinopathy; IL-17A; Retinal pathology.
Published by Elsevier Inc.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Capillary Permeability / genetics*
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Capillary Permeability / immunology
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Diabetes Mellitus, Experimental / genetics*
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Diabetes Mellitus, Experimental / immunology
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Diabetes Mellitus, Experimental / pathology
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Diabetic Retinopathy / genetics*
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Diabetic Retinopathy / immunology
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Diabetic Retinopathy / pathology
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Endothelial Cells / immunology*
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Endothelial Cells / pathology
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Ependymoglial Cells / immunology*
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Ependymoglial Cells / pathology
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Gene Expression Regulation
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Inflammation
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Interleukin-17 / deficiency
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Interleukin-17 / genetics*
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Interleukin-17 / immunology
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Male
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Mice
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Mice, Inbred C57BL
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Mice, Knockout
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Neutrophils / immunology
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Neutrophils / pathology
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Oxidative Stress
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Receptors, Interleukin-17 / genetics
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Receptors, Interleukin-17 / immunology
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Retinal Cone Photoreceptor Cells / immunology
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Retinal Cone Photoreceptor Cells / pathology
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Signal Transduction
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Streptozocin
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T-Lymphocytes / immunology
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T-Lymphocytes / pathology
Substances
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Il17a protein, mouse
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Interleukin-17
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Receptors, Interleukin-17
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Streptozocin