Rhodium(iii)-catalyzed chemoselective C-H functionalization of benzamides with methyleneoxetanones controlled by the solvent

Org Biomol Chem. 2019 Jun 26;17(25):6114-6118. doi: 10.1039/c9ob00645a.

Abstract

Described herein is a Rh(iii)-catalyzed and solvent-controlled double C-H functionalization of common benzamides via selective acyl C-O cleavage (β-H elimination) or alkyl C-O cleavage (β-O elimination) of the methyleneoxetanone substrate, which provides a straightforward way for the divergent synthesis of chain alkylated benzamides and seven-membered 1H-benzo[c]azepine-1,3(2H)-diones in a highly chemoselective manner. Through a series of experimental investigations together with theoretical studies, the effect of the solvent has been systematically elucidated.

Publication types

  • Research Support, Non-U.S. Gov't