Tissue Patterning: The Winner Takes It All, the Losers Standing Small

Sirio Dupont; Leonardo Morsut

doi:10.1016/j.cub.2019.03.026

Tissue Patterning: The Winner Takes It All, the Losers Standing Small

Curr Biol. 2019 May 6;29(9):R334-R337. doi: 10.1016/j.cub.2019.03.026.

Authors

Sirio Dupont¹, Leonardo Morsut²

Affiliations

¹ Department of Molecular Medicine and School of Medicine, University of Padua, Padua, Italy. Electronic address: sirio.dupont@unipd.it.
² Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, and Department of Biomedical Engineering, Viterbi School of Engineering, University of South California, Los Angeles, CA, USA. Electronic address: Leonardo.Morsut@med.usc.edu.

PMID: 31063728
DOI: 10.1016/j.cub.2019.03.026

Abstract

A new mechanism for the selection and differentiation of a single cell, based on mechanical competition with its neighbors and differential TAZ activity, is shown to be at play during zebrafish oogenesis to prevent polyspermy.

Publication types

Comment

MeSH terms

Animals
Cell Communication*
Cell Differentiation
Oogenesis
Zebrafish
Zebrafish Proteins*

Substances

Zebrafish Proteins

Grants and funding

R00 EB021030/EB/NIBIB NIH HHS/United States