Medications that Cause Fetal Anomalies and Possible Prevention Strategies

Clin Perinatol. 2019 Jun;46(2):203-213. doi: 10.1016/j.clp.2019.02.003. Epub 2019 Mar 28.

Abstract

Many conditions that require frequent medication use are common during pregnancy. The purpose of this article is to list some of the most common of these disorders and to discuss the risk to the developing fetus of the medications used most frequently to treat them. Included are drugs used for the treatment of asthma, nausea and vomiting, hyperthyroidism, pain and fever, and depression during pregnancy.

Keywords: Frequently used drugs during pregnancy; Medications; Teratology.

Publication types

  • Review

MeSH terms

  • Abnormalities, Drug-Induced / etiology*
  • Abnormalities, Drug-Induced / prevention & control
  • Acetaminophen / adverse effects
  • Acetaminophen / therapeutic use
  • Adrenal Cortex Hormones / adverse effects
  • Adrenal Cortex Hormones / therapeutic use
  • Adrenergic beta-Agonists / adverse effects
  • Adrenergic beta-Agonists / therapeutic use
  • Analgesics, Non-Narcotic / adverse effects
  • Analgesics, Non-Narcotic / therapeutic use
  • Anti-Asthmatic Agents / adverse effects
  • Anti-Asthmatic Agents / therapeutic use
  • Antidepressive Agents / adverse effects
  • Antidepressive Agents / therapeutic use
  • Antiemetics / adverse effects
  • Antiemetics / therapeutic use
  • Antithyroid Agents / adverse effects
  • Antithyroid Agents / therapeutic use
  • Asthma / drug therapy
  • Congenital Abnormalities / epidemiology*
  • Depressive Disorder / drug therapy
  • Female
  • Humans
  • Hyperthyroidism / drug therapy
  • Leukotriene Antagonists / adverse effects
  • Leukotriene Antagonists / therapeutic use
  • Maternal-Fetal Exchange
  • Methimazole / therapeutic use
  • Morning Sickness / drug therapy
  • Ondansetron / therapeutic use
  • Pregnancy
  • Pregnancy Complications / drug therapy*
  • Propylthiouracil / therapeutic use
  • Teratogens

Substances

  • Adrenal Cortex Hormones
  • Adrenergic beta-Agonists
  • Analgesics, Non-Narcotic
  • Anti-Asthmatic Agents
  • Antidepressive Agents
  • Antiemetics
  • Antithyroid Agents
  • Leukotriene Antagonists
  • Teratogens
  • Acetaminophen
  • Ondansetron
  • Methimazole
  • Propylthiouracil