Experimental Evidence Behind Clinical Trial Outcomes in Retinopathy of Prematurity

Ophthalmic Surg Lasers Imaging Retina. 2019 Apr 1;50(4):228-234. doi: 10.3928/23258160-20190401-05.

Abstract

Treatment of severe retinopathy of prematurity (ROP) has evolved over the last decade. This article reviews recent clinical trials and experimental evidence that supports clinical outcomes and observations, including the efficacy of anti-vascular endothelial growth factor (VEGF) agents in reducing the vascular activity of severe ROP, and the mechanisms behind recurrent stage 3 ROP and plus disease in some infants treated with anti-VEGF agents. Also discussed will be current imaging modalities that link experimental models of ROP with longitudinal human studies and which provide exciting future opportunities to enhance the understanding of pathophysiology of ROP and improve treatments. [Ophthalmic Surg Lasers Imaging Retina. 2019;50:228-234.].

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Angiogenesis Inhibitors / administration & dosage
  • Animals
  • Bevacizumab / administration & dosage*
  • Clinical Trials as Topic*
  • Fluorescein Angiography / methods
  • Fundus Oculi
  • Humans
  • Intravitreal Injections
  • Laser Therapy / methods*
  • Receptors, Vascular Endothelial Growth Factor / antagonists & inhibitors
  • Retinopathy of Prematurity / diagnosis
  • Retinopathy of Prematurity / therapy*
  • Tomography, Optical Coherence / methods

Substances

  • Angiogenesis Inhibitors
  • Bevacizumab
  • Receptors, Vascular Endothelial Growth Factor