New sorbicillinoid derivatives with GLP-1R and eEF2K affinities from a sponge-derived fungus Penicillium chrysogenum 581F1

Min-Jia Cao; Tao Zhu; Jing-Tang Liu; Liang Ouyang; Fan Yang; Hou-Wen Lin

doi:10.1080/14786419.2019.1596099

New sorbicillinoid derivatives with GLP-1R and eEF2K affinities from a sponge-derived fungus Penicillium chrysogenum 581F1

Nat Prod Res. 2020 Oct;34(20):2880-2886. doi: 10.1080/14786419.2019.1596099. Epub 2019 Apr 16.

Authors

Min-Jia Cao¹, Tao Zhu¹, Jing-Tang Liu¹, Liang Ouyang², Fan Yang¹, Hou-Wen Lin¹

Affiliations

¹ Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
² State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu, China.

PMID: 30990084
DOI: 10.1080/14786419.2019.1596099

Abstract

Two new sorbicillinoids, 13-hydroxy-dihydrotrichodermolide (1) and 10,11,27,28-tetrahydrotrisorbicillinone C (2), were isolated from the sponge-derived fungus Penicillium chrysogenum 581F1. Their structures were determined on the basis of spectroscopic analysis. Compounds 1 and 2 displayed high affinities to target proteins GLP-1R (diabetes) and eEF2K (cancer) with K_d values of 0.0285 μM, 0.0162 μM for GLP-1R and 0.118 μM, 0.0746 μM for eEF2K, respectively.

Keywords: Penicillium chrysogenum; Sponge-derived fungus; sorbicillinoid; trisorbicillinone.

MeSH terms

Animals
Cyclohexanones / chemistry*
Cyclohexanones / isolation & purification
Cyclohexanones / metabolism
Elongation Factor 2 Kinase / metabolism*
Glucagon-Like Peptide-1 Receptor / metabolism*
Humans
Molecular Structure
Penicillium chrysogenum / chemistry*
Porifera / microbiology

Substances

Cyclohexanones
Glucagon-Like Peptide-1 Receptor
sorbicillinol
Elongation Factor 2 Kinase