RNA recombination at Chikungunya virus 3'UTR as an evolutionary mechanism that provides adaptability

PLoS Pathog. 2019 Apr 15;15(4):e1007706. doi: 10.1371/journal.ppat.1007706. eCollection 2019 Apr.

Abstract

The potential of RNA viruses to adapt to new environments relies on their ability to introduce changes in their genomes, which has resulted in the recent expansion of re-emergent viruses. Chikungunya virus is an important human pathogen transmitted by mosquitoes that, after 60 years of exclusive circulation in Asia and Africa, has rapidly spread in Europe and the Americas. Here, we examined the evolution of CHIKV in different hosts and uncovered host-specific requirements of the CHIKV 3'UTR. Sequence repeats are conserved at the CHIKV 3'UTR but vary in copy number among viral lineages. We found that these blocks of repeated sequences favor RNA recombination processes through copy-choice mechanism that acts concertedly with viral selection, determining the emergence of new viral variants. Functional analyses using a panel of mutant viruses indicated that opposite selective pressures in mosquito and mammalian cells impose a fitness cost during transmission that is alleviated by recombination guided by sequence repeats. Indeed, drastic changes in the frequency of viral variants with different numbers of repeats were detected during host switch. We propose that RNA recombination accelerates CHIKV adaptability, allowing the virus to overcome genetic bottlenecks within the mosquito host. These studies highlight the role of 3'UTR plasticity on CHIKV evolution, providing a new paradigm to explain the significance of sequence repetitions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3' Untranslated Regions / genetics*
  • Aedes / genetics
  • Aedes / virology*
  • Animals
  • Base Sequence
  • Cells, Cultured
  • Chikungunya Fever / genetics
  • Chikungunya Fever / transmission
  • Chikungunya Fever / virology*
  • Chikungunya virus / pathogenicity*
  • Evolution, Molecular
  • Fibroblasts / cytology
  • Fibroblasts / metabolism
  • Fibroblasts / virology
  • Humans
  • RNA / genetics*
  • RNA, Viral / genetics
  • Recombination, Genetic*
  • Repetitive Sequences, Nucleic Acid
  • Virus Replication / genetics*

Substances

  • 3' Untranslated Regions
  • RNA, Viral
  • RNA, recombinant
  • RNA

Grants and funding

C.V.F. and D.E.A. are members of the Argentinean Council of Investigation (CONICET). This work was supported by a grant from the Agencia Nacional de Promoción Científica y Tecnológica awarded to C.V.F. (PICT-201-0001) and by the French Government's Investissement d'Avenir program, Laboratoire d'Excellence Integrative Biology of Emerging Infectious Diseases awarded to M.C.S. (ANR-10-LABX-62-IBEID). URL of funders websites: http://www.agencia.mincyt.gob.ar/frontend/agencia/instrumento/24http://www.agence-nationale-recherche.fr/ The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.