Trim71/lin-41 Links an Ancient miRNA Pathway to Human Congenital Hydrocephalus

Trends Mol Med. 2019 Jun;25(6):467-469. doi: 10.1016/j.molmed.2019.03.004. Epub 2019 Apr 8.

Abstract

Tripartite motif 71 (Trim71)/lineage defective 41 (lin-41) is the primary target of the ancient lethal 7 (let-7) miRNA that is essential for survival and development across animal phylogeny. Recent work identified Trim71 as a critical regulator of mammalian neural stem cell (NSC) fate and a bona fide human disease gene in congenital hydrocephalus (CH). Studying TRIM71 as a paradigm of NSC involvement in CH is a remarkable opportunity to better understand the mechanisms that regulate the timing of brain development and the pathogenesis of the most common pediatric neurosurgical disorder.

Keywords: Trim71; brain development; congenital hydrocephalus; let-7; lin-41; neural stem cell.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brain / abnormalities
  • Brain / embryology
  • Brain / metabolism
  • Genetic Predisposition to Disease
  • Humans
  • Hydrocephalus / diagnosis
  • Hydrocephalus / genetics*
  • MicroRNAs / genetics*
  • Neural Stem Cells / metabolism
  • Neurogenesis / genetics
  • Transcription Factors / genetics*
  • Tripartite Motif Proteins / genetics*
  • Ubiquitin-Protein Ligases / genetics*

Substances

  • MicroRNAs
  • Transcription Factors
  • Tripartite Motif Proteins
  • TRIM71 protein, human
  • Ubiquitin-Protein Ligases