Treatment of severe psoriasis with ixekizumab in a liver transplant recipient with concomitant hepatitis B virus infection

Dermatol Ther. 2019 May;32(3):e12909. doi: 10.1111/dth.12909. Epub 2019 Apr 23.

Abstract

Treatment of severe psoriasis (PsO) in organ transplant (OT) patients is difficult. In fact, systemic drugs used for PsO therapy can be detrimental to transplanted organs and/or can increase the risk of serious infections in subjects already taking antireject medicines. Current guidelines fail to give indications on how to manage PsO OT subjects. Moreover, only a few cases of patients with the above-cited characteristics treated with systemic therapies have been published so far. Here, we report our experience concerning a liver transplant patient successfully treated with ixekizumab for his psoriasis throughout 1 year.

Keywords: ixekizumab; organ transplant; psoriasis.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Antibodies, Monoclonal, Humanized / therapeutic use*
  • Hepatitis B / complications*
  • Humans
  • Liver Transplantation*
  • Male
  • Middle Aged
  • Psoriasis / drug therapy*

Substances

  • Antibodies, Monoclonal, Humanized
  • ixekizumab