RETRACTED: Osthole attenuates APP-induced Alzheimer's disease through up-regulating miRNA-101a-3p

Life Sci. 2019 May 15:225:117-131. doi: 10.1016/j.lfs.2019.04.004. Epub 2019 Apr 3.

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of Editor-in-Chief. The journal was initially contacted by the corresponding author to request the retraction of the article because the “same pictures were confused” in Figure 3B. The further investigation of the editor found that Dr. Elisabeth Bik has pointed out some problems of this article, including similarities between features and sections of panels within Figures 3A and 3B, as well as between Western Blots within Figures 6A,B, 8C and 10A,B, and therefore the Editor has decided to retract the article.

Keywords: Alzheimer's disease; Amyloid precursor protein; MicroRNA-101a-3p; Microarray; Osthole.

Publication types

  • Retracted Publication

MeSH terms

  • Alzheimer Disease / etiology
  • Alzheimer Disease / genetics
  • Alzheimer Disease / prevention & control*
  • Amyloid beta-Protein Precursor / metabolism*
  • Animals
  • Calcium Channel Blockers / pharmacology*
  • Coumarins / pharmacology*
  • Disease Models, Animal
  • Gene Expression Regulation / drug effects*
  • Humans
  • Maze Learning
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • MicroRNAs / genetics*
  • Neuroblastoma / drug therapy
  • Neuroblastoma / metabolism
  • Neuroblastoma / pathology
  • Presenilin-1 / metabolism
  • Tumor Cells, Cultured
  • Up-Regulation

Substances

  • Amyloid beta-Protein Precursor
  • Calcium Channel Blockers
  • Coumarins
  • MIRN101 microRNA, rat
  • MicroRNAs
  • Presenilin-1
  • osthol