Platelets Give a Running Start to Adult Hippocampal Neurogenesis

Adam B Schroer; Alana M Horowitz; Saul A Villeda

doi:10.1016/j.stemcr.2019.03.007

Platelets Give a Running Start to Adult Hippocampal Neurogenesis

Stem Cell Reports. 2019 Apr 9;12(4):643-646. doi: 10.1016/j.stemcr.2019.03.007.

Authors

Adam B Schroer¹, Alana M Horowitz², Saul A Villeda³

Affiliations

¹ Department of Anatomy, University of California San Francisco, San Francisco, CA, USA.
² Department of Anatomy, University of California San Francisco, San Francisco, CA, USA; Biomedical Sciences Graduate Program, University of California San Francisco, San Francisco, CA, USA.
³ Department of Anatomy, University of California San Francisco, San Francisco, CA, USA; Biomedical Sciences Graduate Program, University of California San Francisco, San Francisco, CA, USA; Department of Physical Therapy and Rehabilitation Science, San Francisco, CA, USA; The Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, San Francisco, CA, USA. Electronic address: saul.villeda@ucsf.edu.

Abstract

Exercise boosts neural stem and progenitor cell proliferation and differentiation in the dentate gyrus region of the hippocampus. In this issue of Stem Cell Reports, Leiter et al. (2019) identify acute exercise-induced platelet activation and platelet factor-4 as novel systemic mediators of adult hippocampal neurogenesis.

Publication types

Letter

MeSH terms

Adult
Animals
Biomarkers
Blood Platelets / metabolism*
Hippocampus / physiology*
Humans
Mice
Models, Animal
Neural Stem Cells / cytology
Neural Stem Cells / metabolism
Neurogenesis*
Platelet Activation

Substances

Biomarkers

Grants and funding

T32 GM008568/GM/NIGMS NIH HHS/United States