The role of disordered angiogenesis tissue markers (sflt-1, Plgf) in present day diagnosis of preeclampsia

Ginekol Pol. 2019;90(3):173-176. doi: 10.5603/GP.2019.0030.

Abstract

Preeclampsia and conditions associated with impaired placental perfusion develop in almost 10% of all pregnancies. Patho- logic angiogenesis is one of the processes observed in preeclampsia. sFlt-1, PlGF and the sFlt-1/PlGF ratio are new and promising angiogenesis-related biomarkers. Our paper describes the present status of, and clinical practice opportunities for, these factors. According to present data, sFlt-1, PlGF and the sFlt-1/PlGF ratio are very useful tools in assessing placental angiogenesis abnormalities associated with preeclampsia and can be use in clinical practice.

Keywords: PlGF; preeclampsia; sFlt-1.

Publication types

  • Review

MeSH terms

  • Female
  • Humans
  • Placenta Growth Factor* / metabolism
  • Placenta Growth Factor* / physiology
  • Pre-Eclampsia* / diagnosis
  • Pre-Eclampsia* / metabolism
  • Pre-Eclampsia* / physiopathology
  • Pregnancy
  • Vascular Endothelial Growth Factor Receptor-1* / metabolism
  • Vascular Endothelial Growth Factor Receptor-1* / physiology

Substances

  • PGF protein, human
  • Placenta Growth Factor
  • FLT1 protein, human
  • Vascular Endothelial Growth Factor Receptor-1