Disseminated Mycosis by Arthrocladium fulminans Jeopardizing a Patient with GATA2 Deficiency

Respiration. 2019;97(5):472-475. doi: 10.1159/000493429. Epub 2019 Mar 29.

Abstract

GATA2 deficiency is characterized by monocytopenia, deficiency of dendritic cells, and a variable degree of lymphocytopenia affecting B cells and NK cells, leading to an enhanced risk of mycobacterial, viral, and fungal infections. Here we present a patient with a heterozygous intronic GATA2 mutation who acquired a fatal disseminated mycosis due to the black yeast-like fungus Arthrocladium fulminans following an infection with Mycobacterium sherrisii. This case illustrates that in patients with severe uncommon infections, immunodeficiency syndromes must be ruled out.

Keywords: Arthrocladium fulminans; GATA2; Immunodeficiency syndrome; Melanized fungus; MonoMAC; Mycobacterium sherrisii.

Publication types

  • Case Reports

MeSH terms

  • Antifungal Agents / administration & dosage*
  • Brain / diagnostic imaging
  • Bronchoscopy / methods
  • Clinical Deterioration
  • Fatal Outcome
  • Female
  • Fungi* / isolation & purification
  • Fungi* / pathogenicity
  • GATA2 Deficiency* / diagnosis
  • GATA2 Deficiency* / immunology
  • GATA2 Deficiency* / physiopathology
  • GATA2 Deficiency* / therapy
  • GATA2 Transcription Factor / genetics
  • Humans
  • Immunologic Deficiency Syndromes* / blood
  • Immunologic Deficiency Syndromes* / diagnosis
  • Immunologic Deficiency Syndromes* / therapy
  • Invasive Fungal Infections* / diagnosis
  • Invasive Fungal Infections* / immunology
  • Invasive Fungal Infections* / physiopathology
  • Invasive Fungal Infections* / therapy
  • Lung* / diagnostic imaging
  • Lung* / microbiology
  • Mutation
  • Tomography, X-Ray Computed / methods
  • Young Adult

Substances

  • Antifungal Agents
  • GATA2 Transcription Factor
  • GATA2 protein, human