Abstract
The first synthetic carbohydrate based potential anti-Salmonella Enteritidis vaccine has been developed by conjugating a synthetic tetrasaccharide antigen with bacteriophage Qβ. High levels of specific and long lasting anti-glycan IgG antibodies were induced by the conjugate, which completely protected mice from lethal bacterial challenges in a passive transfer model.
MeSH terms
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Allolevivirus / chemistry
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Allolevivirus / immunology
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Animals
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Antibodies, Bacterial / immunology
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Antibodies, Bacterial / therapeutic use
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Immunoglobulin G / immunology
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Immunoglobulin G / therapeutic use
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Mice
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O Antigens / chemistry
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O Antigens / immunology
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O Antigens / metabolism*
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Oligosaccharides / chemical synthesis*
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Oligosaccharides / chemistry
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Oligosaccharides / immunology
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Salmonella Infections, Animal / mortality
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Salmonella Infections, Animal / prevention & control
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Salmonella Infections, Animal / therapy
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Salmonella Vaccines / immunology*
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Salmonella enteritidis / metabolism*
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Salmonella enteritidis / pathogenicity
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Survival Rate
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Vaccines, Virus-Like Particle / chemistry
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Vaccines, Virus-Like Particle / immunology
Substances
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Antibodies, Bacterial
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Immunoglobulin G
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O Antigens
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Oligosaccharides
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Salmonella Vaccines
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Vaccines, Virus-Like Particle