Noncirrhotic portal hypertension: An under-reported late adverse event of SIRT in metastatic colorectal cancer patients

J Cancer Res Ther. 2019 Jan-Mar;15(1):42-47. doi: 10.4103/jcrt.JCRT_1398_16.

Abstract

Introduction: Selective internal radiation therapy (SIRT) is increasingly used in different scenarios. Although portal hypertension (PHT) has been described as a nonclinically relevant finding after SIRT, its real incidence could have been neglected due to the nature of the diseases for which SIRT is indicated.

Case reports: Here we report three cases with clinically relevant late PHT after treatments including SIRT and oxaliplatin among others.

Discussion: The sequential use of oxaliplatin and SIRT in patients with colorectal cancer metastases could have additive effects on the liver.

Keywords: Late toxicity; SIRT; liver metastases; portal hypertension; regenerative nodular hyperplasia.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects
  • Biopsy
  • Brachytherapy / adverse effects*
  • Brachytherapy / methods
  • Chemoradiotherapy, Adjuvant / adverse effects
  • Chemoradiotherapy, Adjuvant / methods
  • Colorectal Neoplasms / therapy*
  • Female
  • Humans
  • Hypertension, Portal / diagnosis
  • Hypertension, Portal / etiology*
  • Hypertension, Portal / pathology
  • Male
  • Microspheres
  • Middle Aged
  • Radiation Injuries / diagnosis
  • Radiation Injuries / etiology*
  • Radiation Injuries / pathology
  • Time Factors
  • Treatment Outcome
  • Yttrium Radioisotopes / administration & dosage
  • Yttrium Radioisotopes / adverse effects

Substances

  • Yttrium Radioisotopes
  • Yttrium-90