Physics of growing biological tissues: the complex cross-talk between cell activity, growth and resistance

Philos Trans A Math Phys Eng Sci. 2019 May 6;377(2144):20180070. doi: 10.1098/rsta.2018.0070.

Abstract

For many organisms, shapes emerge from growth, which generates stresses, which in turn can feedback on growth. In this review, theoretical methods to analyse various aspects of morphogenesis are discussed with the aim to determine the most adapted method for tissue mechanics. We discuss the need to work at scales intermediate between cells and tissues and emphasize the use of finite elasticity for this. We detail the application of these ideas to four systems: active cells embedded in tissues, brain cortical convolutions, the cortex of Caenorhabditis elegans during elongation and finally the proliferation of epithelia on extracellular matrix. Numerical models well adapted to inhomogeneities are also presented. This article is part of the theme issue 'Rivlin's legacy in continuum mechanics and applied mathematics'.

Keywords: active and multi-scale rheology; finite elasticity; morphogenesis; tissue growth; tissue mechanics.

Publication types

  • Review

MeSH terms

  • Animals
  • Biomechanical Phenomena
  • Biophysical Phenomena
  • Caenorhabditis elegans / embryology
  • Cell Physiological Phenomena*
  • Cell Proliferation
  • Cerebral Cortex / growth & development
  • Connective Tissue Cells / physiology
  • Elasticity
  • Humans
  • Models, Biological*
  • Morphogenesis / physiology*