Novel influenza A(H1N2) seasonal reassortant identified in a patient sample, Sweden, January 2019

Euro Surveill. 2019 Feb;24(9):1900124. doi: 10.2807/1560-7917.ES.2019.24.9.1900124.

Abstract

In January 2019, a human seasonal reassortant influenza A(H1N2) virus with a novel 7:1 genetic constellation was identified in a 68-year-old female patient with suspected pneumonia. The virus harboured A(H3N2) neuraminidase and remaining genes from A(H1N1)pdm09. The patient recovered after severe illness. No additional cases have been detected. This is the second identified A(H1N2) seasonal reassortant in a human in Europe within 1 year; a previous case was detected in the Netherlands in March 2018.

Keywords: Sweden; haemagglutinin; human influenza; neuraminidase; reassortant viruses; surveillance; whole genome sequencing.

MeSH terms

  • Aged
  • Antiviral Agents / therapeutic use
  • Female
  • Humans
  • Influenza A Virus, H1N1 Subtype / genetics
  • Influenza A Virus, H1N2 Subtype / genetics
  • Influenza A Virus, H1N2 Subtype / isolation & purification*
  • Influenza A Virus, H3N2 Subtype / genetics
  • Influenza, Human / diagnosis*
  • Influenza, Human / drug therapy
  • Influenza, Human / virology
  • Nasopharynx / virology*
  • Neuraminidase / genetics
  • Oseltamivir / therapeutic use
  • Polymerase Chain Reaction
  • Reassortant Viruses / genetics
  • Reassortant Viruses / isolation & purification*
  • Seasons
  • Treatment Outcome

Substances

  • Antiviral Agents
  • Oseltamivir
  • Neuraminidase