Free-radical and biochemical reactions involving polar part of glycerophospholipids

Abstract

The review summarizes and critically discusses data on biochemical and free-radical transformations of glycerophospholipids. The results presented therein demonstrate that hydroxyl-containing glycerophospholipids, such as cardiolipin, lyso-lipids and others, can undergo fragmentation upon interaction with radical agents forming the biologically active products. Hydrolysis of glycerophospholipids catalyzed by different phospholipases was shown to yield compounds, which can be involved in the free-radical fragmentation leading to significant changes in structures of original lipids.

Keywords: Free-radical fragmentation; Glycerophospholipids; Inhibitors; Phospholipases.