Abstract
Ketamine is the first exemplar of a rapid-acting antidepressant with efficacy for treatment-resistant symptoms of mood disorders. Its discovery emerged from a reconceptualization of the biology of depression. Neurobiological insights into ketamine efficacy shed new light on the mechanisms underlying antidepressant efficacy.
Published by Elsevier Inc.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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Animals
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Antidepressive Agents / adverse effects
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Antidepressive Agents / pharmacology
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Antidepressive Agents / therapeutic use*
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Excitatory Amino Acid Antagonists / adverse effects
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Excitatory Amino Acid Antagonists / pharmacology
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Excitatory Amino Acid Antagonists / therapeutic use*
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Humans
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Ketamine / adverse effects
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Ketamine / pharmacology
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Ketamine / therapeutic use*
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Synaptic Transmission / drug effects
Substances
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Antidepressive Agents
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Excitatory Amino Acid Antagonists
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Ketamine