The MALT1 locus and peanut avoidance in the risk for peanut allergy

Alexandra Winters; Henry T Bahnson; Ingo Ruczinski; Meher P Boorgula; Claire Malley; Ali R Keramati; Sameer Chavan; David Larson; Karen Cerosaletti; Peter H Sayre; Marshall Plaut; George Du Toit; Gideon Lack; Kathleen C Barnes; Gerald T Nepom; Rasika A Mathias; Immune Tolerance Network LEAP Study Team

doi:10.1016/j.jaci.2019.02.016

The MALT1 locus and peanut avoidance in the risk for peanut allergy

J Allergy Clin Immunol. 2019 Jun;143(6):2326-2329. doi: 10.1016/j.jaci.2019.02.016. Epub 2019 Feb 27.

Authors

Alexandra Winters¹, Henry T Bahnson², Ingo Ruczinski³, Meher P Boorgula⁴, Claire Malley¹, Ali R Keramati¹, Sameer Chavan⁴, David Larson⁵, Karen Cerosaletti⁶, Peter H Sayre⁷, Marshall Plaut⁸, George Du Toit⁹, Gideon Lack⁹, Kathleen C Barnes⁴, Gerald T Nepom⁵, Rasika A Mathias¹⁰; Immune Tolerance Network LEAP Study Team

Affiliations

¹ Department of Medicine, Johns Hopkins University, Baltimore, Md.
² Benaroya Research Institute, Seattle, Wash; Immune Tolerance Network, San Francisco, Calif.
³ Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Md.
⁴ Department of Medicine, University of Colorado, Anschutz, Colo.
⁵ Immune Tolerance Network, San Francisco, Calif.
⁶ Benaroya Research Institute, Seattle, Wash.
⁷ Immune Tolerance Network, San Francisco, Calif; Department of Medicine, University of California, San Francisco, Calif.
⁸ Allergy, Asthma and Airway Biology Branch, Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, Bethesda, Md.
⁹ Department of Pediatric Allergy, Division of Asthma, Allergy and Lung Biology, King's College London, and Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom.
¹⁰ Department of Medicine, Johns Hopkins University, Baltimore, Md. Electronic address: rmathias@jhmi.edu.

Abstract

We identified a strong association between peanut allergy and the MALT1 locus in LEAP participants in the peanut avoidance group with 58.6% of carriers developing peanut allergy at 60 months as compared to 12.7% of non-carriers.

Publication types

Controlled Clinical Trial
Letter
Research Support, N.I.H., Extramural

MeSH terms

Allergens / immunology
Arachis / immunology
Child
Female
Genetic Loci
Genetic Predisposition to Disease
Humans
Immunoglobulin E / immunology
Male
Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein / genetics*
Peanut Hypersensitivity / genetics*
Risk

Substances

Allergens
Immunoglobulin E
MALT1 protein, human
Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein

Grants and funding

UM1 AI109565/AI/NIAID NIH HHS/United States