On the short-loop feedback regulation of the hypothalamic luteinizing hormone releasing hormone 'pulse generator' in the rhesus monkey

Neuroendocrinology. 1986;42(2):109-11. doi: 10.1159/000124259.

Abstract

The characteristic electrophysiological manifestations of LHRH 'pulse generator' activity were unaffected by prolonged elevations in plasma LH concentrations achieved by the administration of a long-acting LHRH agonist. These findings do not lend support to the existence of a 'short-loop feedback' inhibition of LHRH 'pulse generator' activity by LH.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Buserelin / pharmacology
  • Electrophysiology
  • Feedback
  • Female
  • Gonadotropin-Releasing Hormone / metabolism*
  • Homeostasis
  • Hypothalamus / drug effects
  • Hypothalamus / physiology*
  • Luteinizing Hormone / metabolism
  • Macaca / physiology*
  • Macaca mulatta / physiology*

Substances

  • Gonadotropin-Releasing Hormone
  • Luteinizing Hormone
  • Buserelin