Corneal ulceration associated with Nivolumab use

Jack S Parker; Wyatt Feagin; Christopher Wang; Marius Heersink; John S Parker

doi:10.1016/j.ajoc.2019.01.013

Corneal ulceration associated with Nivolumab use

Am J Ophthalmol Case Rep. 2019 Feb 7:14:26-27. doi: 10.1016/j.ajoc.2019.01.013. eCollection 2019 Jun.

Authors

Jack S Parker^{1

2}, Wyatt Feagin³, Christopher Wang⁴, Marius Heersink⁵, John S Parker¹

Affiliations

¹ Parker Cornea, 1720 University Blvd Suite 503, Birmingham, AL, 35233, USA.
² Netherlands Institute for Innovative Ocular Surgery (NIIOS), Laan op Zuid 88 - 3071 AA Rotterdam, Rotterdam, NL, the Netherlands.
³ Alabama Eye Ophthalmology Associates, 1009 Montgomery Hwy #200, Birmingham, AL, 35216, USA.
⁴ Alabama Oncology Brookwood, 2022 Medical Center Drive, Suite 628, Birmingham, AL, 35209, USA.
⁵ University of Alabama at Birmingham School of Medicine, 1670 University Blvd, Birmingham, AL, 35233, USA.

Abstract

Purpose: To describe a case of corneal ulceration associated with Nivolumab use.

Observations: An 80-year-old woman treated with Nivolumab for metastatic melanoma developed an intractable corneal ulcer in her left eye, refractory to all therapies - including surgery to cover the ulcer with a conjunctival flap - until topical prednisolone acetate was tried, which was curative.

Conclusions and importance: Nivolumab use may be associated with a form of steroid-responsive corneal ulceration.

Keywords: Cornea; Corneal ulcer; Nivolumab; Opdivo; Peripheral ulcerative keratitis.

Publication types

Case Reports