Abstract
In this work, we have developed a novel and highly selective signal amplification strategy based on target-assisted self-cleavage DNAzyme probes for multicolor and simultaneous imaging of miRNA-222 and miRNA-223 in living cells. The fluctuation of miRNA-222 and miRNA-223 expression levels could also be monitored.
MeSH terms
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Cell Line, Tumor
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Color
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DNA, Catalytic / chemistry*
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Humans
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Hydrolysis
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MicroRNAs / chemistry*
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Molecular Probes / chemistry*
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Nucleic Acid Amplification Techniques / methods*
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RNA, Neoplasm / genetics*
Substances
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DNA, Catalytic
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MIRN222 microRNA, human
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MIRN223 microRNA, human
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MicroRNAs
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Molecular Probes
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RNA, Neoplasm