Role of Paip1 on angiogenesis and invasion in pancreatic cancer

Exp Cell Res. 2019 Mar 15;376(2):198-209. doi: 10.1016/j.yexcr.2019.01.017. Epub 2019 Feb 4.

Abstract

Poly(A)-binding protein-interacting protein 1 (Paip1) was discovered as a modulator of translation initiation as a result of binding to PABP. Increasing evidence suggested that Paip1 has been implicated in several pathogenic roles. However, its clinical significance and underlying molecular mechanisms in Pancreatic cancer (PC) remain uncertain. In our present study, we found that Paip1 was over-expressed in human PC tissues. As well as poor survival, the over-expression of Paip1 was associated with lymph node (LN) metastasis of the PC samples analyzed. Paip1 silencing inhibits PC cell proliferation, metastasis, and angiogenesis, whereas over-expression of Paip1 produces the opposite effects. In all, we proposed that Paip1 contributes to PC progression and appears to be a valid prognostic factor of PC.

Keywords: Angiogenesis; Metastasis; Paip1; Pancreatic cancer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers, Tumor / metabolism
  • Cell Line, Tumor
  • Cell Movement
  • Cell Proliferation
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Invasiveness
  • Neovascularization, Pathologic*
  • Pancreatic Neoplasms / blood supply
  • Pancreatic Neoplasms / metabolism*
  • Pancreatic Neoplasms / pathology
  • Pancreatic Neoplasms / physiopathology*
  • Peptide Initiation Factors / metabolism*
  • Prognosis
  • RNA-Binding Proteins / metabolism*
  • Up-Regulation

Substances

  • Biomarkers, Tumor
  • PAIP1 protein, human
  • Peptide Initiation Factors
  • RNA-Binding Proteins