Early season estimate of influenza vaccination effectiveness against influenza hospitalisation in children, Hong Kong, winter influenza season 2018/19

Euro Surveill. 2019 Jan;24(5):1900056. doi: 10.2807/1560-7917.ES.2019.24.5.1900056.

Abstract

The winter 2018/19 influenza season in Hong Kong has been predominated by influenza A(H1N1)pdm09 as at January 2019. We enrolled 2,016 children in three public hospitals in Hong Kong between 2 September 2018 and 11 January 2019. Using the test-negative approach, we estimated high early season effectiveness of inactivated influenza vaccine against influenza A or B of 90% (95% confidence interval (CI): 80-95%) and 92% (95% CI: 82-96%) against influenza A(H1N1)pdm09.

Keywords: H1N1; Hong Kong; children; hospital; inactivated influenza vaccination; influenza; public health; vaccine effectiveness; winter.

MeSH terms

  • Adolescent
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Female
  • Hong Kong / epidemiology
  • Hospitalization / statistics & numerical data*
  • Humans
  • Infant
  • Influenza A Virus, H1N1 Subtype / immunology
  • Influenza A Virus, H1N1 Subtype / isolation & purification*
  • Influenza A virus / immunology
  • Influenza A virus / isolation & purification*
  • Influenza B virus / immunology
  • Influenza B virus / isolation & purification*
  • Influenza Vaccines / administration & dosage*
  • Influenza Vaccines / immunology
  • Influenza, Human / diagnosis*
  • Influenza, Human / epidemiology
  • Influenza, Human / prevention & control*
  • Male
  • Public Health Surveillance
  • Seasons
  • Vaccination / statistics & numerical data
  • Vaccine Potency*
  • Vaccines, Inactivated / administration & dosage*

Substances

  • Influenza Vaccines
  • Vaccines, Inactivated