A perfect storm: Genetics and anticommensal antibodies shore up type 1 diabetes

Jacob M Luber; Aleksandar D Kostic

doi:10.1126/sciimmunol.aaw3345

A perfect storm: Genetics and anticommensal antibodies shore up type 1 diabetes

Sci Immunol. 2019 Feb 1;4(32):eaaw3345. doi: 10.1126/sciimmunol.aaw3345.

Authors

Jacob M Luber^{1

2

3

4}, Aleksandar D Kostic^{1

2

4}

Affiliations

¹ Section on Pathophysiology and Molecular Pharmacology, Joslin Diabetes Center, Boston, MA 02215, USA. jluber@g.harvard.edu aleksandar.kostic@joslin.harvard.edu.
² Section on Islet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, MA 02215, USA.
³ Division of Medical Sciences, Harvard Medical School, Boston, MA 02115, USA.
⁴ Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA.

PMID: 30709844
DOI: 10.1126/sciimmunol.aaw3345

Abstract

HLA haplotypes in conjunction with serum anticommensal antibody responses are predictive of type 1 diabetes progression. See related Research Article by Paun et al.

Publication types

Review
Comment

MeSH terms

Antibodies
Antibody Formation
Autoimmunity
Bacteria
Child
Diabetes Mellitus, Type 1*
Humans

Substances

Antibodies