Construction of arabinogalactans/selenium nanoparticles composites for enhancement of the antitumor activity

Shuo Tang; Ting Wang; Meiyun Jiang; Caoxing Huang; Chenhuan Lai; Yimin Fan; Qiang Yong

doi:10.1016/j.ijbiomac.2019.01.152

Construction of arabinogalactans/selenium nanoparticles composites for enhancement of the antitumor activity

Int J Biol Macromol. 2019 May 1:128:444-451. doi: 10.1016/j.ijbiomac.2019.01.152. Epub 2019 Jan 28.

Authors

Shuo Tang¹, Ting Wang², Meiyun Jiang³, Caoxing Huang⁴, Chenhuan Lai⁵, Yimin Fan⁶, Qiang Yong⁷

Affiliations

¹ Co-Innovation Center for Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China. Electronic address: stantontang@njfu.edu.cn.
² Co-Innovation Center for Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China. Electronic address: wangting162428@njfu.edu.cn.
³ Co-Innovation Center for Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China. Electronic address: jmy1115@njfu.edu.cn.
⁴ Co-Innovation Center for Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China. Electronic address: hcx@njfu.edu.cn.
⁵ Co-Innovation Center for Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China. Electronic address: lch2014@njfu.edu.cn.
⁶ Co-Innovation Center for Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China. Electronic address: fanyimin@njfu.edu.cn.
⁷ Co-Innovation Center for Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China. Electronic address: swhx@njfu.com.cn.

PMID: 30703423
DOI: 10.1016/j.ijbiomac.2019.01.152

Abstract

Selenium nanoparticles (SeNPs) were synthesized using arabinogalactans (LAG) as a formation scaffolding and particle stabilizer to investigate their anti-tumor properties. The formation, morphology, size, and in vitro biological activity of LAG-SeNPs were characterized by UV-vis, FT-IR, scanning electron microscopy (SEM), transmission electron microscopy (TEM), dynamic light scattering (DLS) and cell toxicity assays. SEM and TEM of LAG-SeNPs visualized the individual spherical nanoparticles, while the spectroscopic characterization revealed the modes of interaction which lead to the stable particle properties of the LAG-SeNPs. Cell toxicity assays indicated that the products had significant inhibitory effect on A549, HepG-2 and MCF-7 cells with a dose-dependent effect. The toxicity mechanisms of LAG-SeNPs were further investigated, and assay results revealed that LAG-SeNPs mainly induced cancer cellular apoptosis to promote atrophy and inhibit cell proliferation. The sum of these findings demonstrates the positive effects that a biomass-derived polysaccharide exert upon non-metal/metalloid-based nanoparticles and the ensuing material's viability as treatment against human cancers.

Keywords: Anticancer; Arabinogalactan; Selenium nanoparticle.

MeSH terms

Antineoplastic Agents / chemistry*
Antineoplastic Agents / pharmacology*
Apoptosis / drug effects
Cell Cycle / drug effects
Cell Line, Tumor
Galactans / chemistry*
Humans
Nanocomposites / chemistry*
Nanoparticles / chemistry*
Particle Size
Selenium / chemistry*

Substances

Antineoplastic Agents
Galactans
Selenium
arabinogalactan