Abstract
We reported methionine bis-alkylated nonapeptide Wpc as an efficient siRNA vehicle previously. Herein, we report an aptamer could also spontaneously coassemble with Wpc to form uniformed nanoparticles for efficient delivery. This unique peptide-based aptamer nanocarrier showed significantly improved cell penetration and antiproliferation effect with high biocompatibility toward various cancer cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkylation
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Aptamers, Nucleotide / chemistry*
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Cell Line, Tumor
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Drug Carriers / chemistry
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Humans
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Methionine / analogs & derivatives
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Nanoparticles / chemistry*
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Neoplasms / genetics
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Neoplasms / therapy*
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Peptides / chemistry*
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RNA, Small Interfering / administration & dosage*
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RNA, Small Interfering / genetics
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RNA, Small Interfering / therapeutic use
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RNAi Therapeutics
Substances
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Aptamers, Nucleotide
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Drug Carriers
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Peptides
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RNA, Small Interfering
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Methionine