CD8+ T-Cell-Derived Tumor Necrosis Factor Can Induce Tissue Factor Expression on Monocytes

J Infect Dis. 2019 Jun 5;220(1):73-77. doi: 10.1093/infdis/jiz051.

Abstract

Circulating CD8+ T cells and monocytes are activated during human immunodeficiency virus (HIV) infection and colocalize in the aortas of simian immunodeficiency virus-infected nonhuman primates. We hypothesized that CD8+ T cells could exert a proatherosclerotic effect via paracrine actions on monocytes. We found that T-cell receptor-stimulated CD8+ T cells induce monocytes to express tissue factor, a potent activator of coagulation. Tumor necrosis factor was both necessary and sufficient for this effect.

Keywords: CD8+ T cells; HIV; TNF; cardiovascular disease; monocytes; tissue factor.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Blood Coagulation / immunology
  • CD8-Positive T-Lymphocytes / immunology*
  • Cells, Cultured
  • Endothelial Cells / immunology
  • HIV Infections / immunology
  • Humans
  • Monocytes / immunology*
  • Receptors, Antigen, T-Cell / immunology
  • Thromboplastin / immunology*
  • Tumor Necrosis Factor-alpha / immunology*

Substances

  • Receptors, Antigen, T-Cell
  • Tumor Necrosis Factor-alpha
  • Thromboplastin