Ocular adhesives: Design, chemistry, crosslinking mechanisms, and applications

Grissel Trujillo-de Santiago; Roholah Sharifi; Kan Yue; Ehsan Shrizaei Sani; Sara Saheb Kashaf; Mario Moisés Alvarez; Jeroen Leijten; Ali Khademhosseini; Reza Dana; Nasim Annabi

doi:10.1016/j.biomaterials.2019.01.011

Ocular adhesives: Design, chemistry, crosslinking mechanisms, and applications

Biomaterials. 2019 Mar:197:345-367. doi: 10.1016/j.biomaterials.2019.01.011. Epub 2019 Jan 7.

Affiliations

¹ Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge 02139, MA, USA; Biomaterials Innovation Research Center, Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston 02139, MA, USA; Microsystems Technologies Laboratories, MIT, Cambridge, 02139, MA, USA; Centro de Biotecnología-FEMSA, Tecnológico de Monterrey, Monterrey, NL 64849, Mexico.
² Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge 02139, MA, USA; Biomaterials Innovation Research Center, Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston 02139, MA, USA.
³ Chemical and Biomolecular Engineering Department, University of California - Los Angeles, Los Angeles, CA 90095, USA.
⁴ Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge 02139, MA, USA; Biomaterials Innovation Research Center, Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston 02139, MA, USA; Department of Developmental BioEngineering, Faculty of Science and Technology, Technical Medicine, University of Twente, Drienerlolaan 5, 7522 NB, Enschede, The Netherlands.
⁵ Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge 02139, MA, USA; Biomaterials Innovation Research Center, Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston 02139, MA, USA; Chemical and Biomolecular Engineering Department, University of California - Los Angeles, Los Angeles, CA 90095, USA; Department of Bioengineering, University of California - Los Angeles, Los Angeles, CA 90095, USA; Center for Minimally Invasive Therapeutics (C-MIT), California NanoSystems Institute (CNSI), University of California - Los Angeles, Los Angeles, CA 90095, USA; Department of Radiology, David Geffen School of Medicine, University of California - Los Angeles, 10833 Le Conte Ave, Los Angeles, CA 90095, USA.
⁶ Massachusetts Eye and Ear Infirmary and Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA.
⁷ Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge 02139, MA, USA; Biomaterials Innovation Research Center, Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston 02139, MA, USA; Chemical and Biomolecular Engineering Department, University of California - Los Angeles, Los Angeles, CA 90095, USA; Center for Minimally Invasive Therapeutics (C-MIT), California NanoSystems Institute (CNSI), University of California - Los Angeles, Los Angeles, CA 90095, USA. Electronic address: nannabi@ucla.edu.

Abstract

Closure of ocular wounds after an accident or surgery is typically performed by suturing, which is associated with numerous potential complications, including suture breakage, inflammation, secondary neovascularization, erosion to the surface and secondary infection, and astigmatism; for example, more than half of post-corneal transplant infections are due to suture related complications. Tissue adhesives provide promising substitutes for sutures in ophthalmic surgery. Ocular adhesives are not only intended to address the shortcomings of sutures, but also designed to be easy to use, and can potentially minimize post-operative complications. Herein, recent progress in the design, synthesis, and application of ocular adhesives, along with their advantages, limitations, and potential are discussed. This review covers two main classes of ocular adhesives: (1) synthetic adhesives based on cyanoacrylates, polyethylene glycol (PEG), and other synthetic polymers, and (2) adhesives based on naturally derived polymers, such as proteins and polysaccharides. In addition, different technologies to cover and protect ocular wounds such as contact bandage lenses, contact lenses coupled with novel technologies, and decellularized corneas are discussed. Continued advances in this area can help improve both patient satisfaction and clinical outcomes.

Keywords: Bioadhesives and sealants; Drug delivery; Natural and synthetic; Ocular.

Published by Elsevier Ltd.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Animals
Bandages
Biocompatible Materials / chemistry
Biocompatible Materials / therapeutic use*
Contact Lenses
Cross-Linking Reagents / therapeutic use
Cyanoacrylates / therapeutic use
Drug Delivery Systems
Eye / pathology
Eye Injuries / therapy*
Humans
Polyethylene Glycols / therapeutic use
Polymers / chemistry
Polymers / therapeutic use*
Polysaccharides / therapeutic use
Proteins / therapeutic use
Tissue Adhesives / therapeutic use*
Wound Healing* / drug effects

Substances

Biocompatible Materials
Cross-Linking Reagents
Cyanoacrylates
Polymers
Polysaccharides
Proteins
Tissue Adhesives
Polyethylene Glycols

Ocular adhesives: Design, chemistry, crosslinking mechanisms, and applications

Authors

Affiliations

Abstract

Publication types

MeSH terms

Substances

Grants and funding