Combined liver and hematopoietic stem cell transplantation in patients with X-linked hyper-IgM syndrome

Giorgia Bucciol; Sarah K Nicholas; Pier Luigi Calvo; Andrew Cant; J David M Edgar; Teresa Español; Francesca Ferrua; Miguel Galicchio; Andrew R Gennery; Nedim Hadzic; I Celine Hanson; Gustavo Kusminsky; Andrzej Lange; Fanny Lanternier; Nizar Mahlaoui; Despina Moshous; Zohreh Nademi; Benedicte Neven; Matias Oleastro; Fulvio Porta; Paola Quarello; Marcelo Silva; Mary A Slatter; Elena Soncini; Marek Stefanowicz; Francesco Tandoi; Mikołaj Teisseyre; Troy R Torgerson; Paul Veys; Katja G Weinacht; Beata Wolska-Kuśnierz; Jacques Pirenne; M Teresa de la Morena; Isabelle Meyts

doi:10.1016/j.jaci.2018.12.1013

Combined liver and hematopoietic stem cell transplantation in patients with X-linked hyper-IgM syndrome

J Allergy Clin Immunol. 2019 May;143(5):1952-1956.e6. doi: 10.1016/j.jaci.2018.12.1013. Epub 2019 Jan 22.

Authors

Giorgia Bucciol¹, Sarah K Nicholas², Pier Luigi Calvo³, Andrew Cant⁴, J David M Edgar⁵, Teresa Español⁶, Francesca Ferrua⁷, Miguel Galicchio⁸, Andrew R Gennery⁴, Nedim Hadzic⁹, I Celine Hanson¹⁰, Gustavo Kusminsky¹¹, Andrzej Lange¹², Fanny Lanternier¹³, Nizar Mahlaoui¹⁴, Despina Moshous¹⁵, Zohreh Nademi¹⁶, Benedicte Neven¹⁷, Matias Oleastro¹⁸, Fulvio Porta¹⁹, Paola Quarello²⁰, Marcelo Silva²¹, Mary A Slatter⁴, Elena Soncini¹⁹, Marek Stefanowicz²², Francesco Tandoi²³, Mikołaj Teisseyre²⁴, Troy R Torgerson²⁵, Paul Veys²⁶, Katja G Weinacht²⁷, Beata Wolska-Kuśnierz²⁸, Jacques Pirenne²⁹, M Teresa de la Morena²⁵, Isabelle Meyts³⁰

Affiliations

¹ Laboratory of Childhood Immunology, Department of Microbiology and Immunology, KU Leuven, and the Department of Pediatrics, University Hospitals Leuven, Leuven, Belgium.
² Solid Organ Transplant Immunology, Section of Immunology, Allergy, and Rheumatology, Baylor College of Medicine and Texas Children's Hospital, Houston, Tex.
³ Pediatric Gastroenterology, Department of Pediatrics, Regina Margherita Children's Hospital, AOU Città della Salute e della Scienza, Turin, Italy.
⁴ Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, and the Primary Immunodeficiency Group, Institute of Cellular Medicine, Newcastle upon Tyne University, Newcastle upon Tyne, United Kingdom.
⁵ Regional Immunology Service, Royal Hospitals, Belfast, United Kingdom.
⁶ Immunology Unit, Vall d'Hebron University Hospital, Barcelona, Spain.
⁷ Department of Pediatric Immunology and HSCT, Great North Children's Hospital, Newcastle upon Tyne, United Kingdom; San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), Pediatric Immunohematology and Bone Marrow Transplantation Unit, San Raffaele Scientific Institute, and Vita-Salute San Raffaele University, Milan, Italy.
⁸ Allergy and Immnunology Service, Hospital de Niños VJ Vilela, Rosario, Argentina.
⁹ Pediatric Center for Hepatology, Gastroenterology and Nutrition, King's College Hospital, London, United Kingdom.
¹⁰ Immunology, Allergy and Rheumatology Section, Baylor College of Medicine and Texas Children's Hospital, Houston, Tex.
¹¹ Stem Cell Transplantation Unit, Austral University Hospital, Buenos Aires, Argentina.
¹² L. Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, and the Lower Silesian Center for Cellular Transplantation with National Bone Marrow Donor Registry, Wroclaw, Poland.
¹³ Service of Infectious and Tropical Diseases, Necker-Enfants Malades University Hospital, Infectiology Center Necker Pasteur, Paris, France; French National Reference Center for Hereditary Immune Deficits (CEREDIH), Necker-Enfants Malades University Hospital, Infectiology Center Necker Pasteur, Paris, France; Paris Descartes University, Sorbonne Paris Cité, Institut Imagine, Paris, France.
¹⁴ French National Reference Center for Hereditary Immune Deficits (CEREDIH), Necker-Enfants Malades University Hospital, Infectiology Center Necker Pasteur, Paris, France; Paris Descartes University, Sorbonne Paris Cité, Institut Imagine, Paris, France; Pediatric Hematology-Immunology and Rheumatology Unit, Necker-Enfants Malades University Hospital, Infectiology Center Necker Pasteur, Paris, France.
¹⁵ Pediatric Hematology-Immunology and Rheumatology Unit, Necker-Enfants Malades University Hospital, Infectiology Center Necker Pasteur, Paris, France.
¹⁶ Immunology Department, Great Ormond Street Hospital for Children, London, United Kingdom.
¹⁷ Paris Descartes University, Sorbonne Paris Cité, Institut Imagine, Paris, France; Pediatric Hematology-Immunology and Rheumatology Unit, Necker-Enfants Malades University Hospital, Infectiology Center Necker Pasteur, Paris, France.
¹⁸ Rheumathology and Immunology Service, Hospital Nacional de Pediatría JP Garrahan, Buenos Aires, Argentina.
¹⁹ Pediatric Hematology Oncology and HSCT Unit, Spedali Civili, Brescia, Italy.
²⁰ Pediatric Oncology-Hematology, Stem Cell Transplantation and Cellular Therapy Division, Regina Margherita Children's Hospital, AOU Città della Salute e della Scienza, Turin, Italy.
²¹ Hepatology Unit, Austral Hospital, Buenos Aires, Argentina.
²² Department of Pediatric Surgery and Organ Transplantation, Children's Memorial Health Institute, Warsaw, Poland.
²³ Liver Transplantation Centre, General Surgery 2U, Department of Surgical Sciences, Molinette Hospital, AOU Città della Salute e della Scienza, Turin, Italy.
²⁴ Department of Gastroenterology, Hepatology, Feeding Disorders and Pediatrics, Children's Memorial Health Institute, Warsaw, Poland.
²⁵ Department of Pediatrics/Immunology, University of Washington and Seattle Children's Research Institute, Seattle, Wash.
²⁶ Bone Marrow Transplant Unit, Great Ormond Street Hospital for Children, London, United Kingdom.
²⁷ Department of Pediatrics, Division of Stem Cell Transplantation and Regenerative Medicine, Stanford School of Medicine, Stanford, Calif.
²⁸ Immunology Department, Children's Memorial Health Institute, Warsaw, Poland.
²⁹ Abdominal Transplantation Surgery, Laboratory of Abdominal Transplantation, University Hospitals Leuven and KU Leuven, Leuven, Belgium.
³⁰ Laboratory of Childhood Immunology, Department of Microbiology and Immunology, KU Leuven, and the Department of Pediatrics, University Hospitals Leuven, Leuven, Belgium. Electronic address: Isabelle.Meyts@uzleuven.be.

PMID: 30682461
DOI: 10.1016/j.jaci.2018.12.1013

No abstract available

Publication types

Case Reports
Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Anti-Bacterial Agents / therapeutic use
Child
Cholangitis, Sclerosing / genetics
Cholangitis, Sclerosing / therapy*
Fatal Outcome
Hematopoietic Stem Cell Transplantation*
Humans
Hyper-IgM Immunodeficiency Syndrome / genetics
Hyper-IgM Immunodeficiency Syndrome / therapy*
Immunoglobulins / therapeutic use
Liver Transplantation*
Lung Diseases / genetics
Lung Diseases / therapy
Young Adult

Substances

Anti-Bacterial Agents
Immunoglobulins