Induced pluripotent stem cell line, ICAGi001-A, derived from human skin fibroblasts of a patient with 2p25.3 deletion and 2p25.3-p23.3 inverted duplication

A A Khabarova; I E Pristyazhnyuk; T V Nikitina; T A Gayner; N B Torkhova; N A Skryabin; A A Kashevarova; N P Babushkina; Zh G Markova; M E Minzhenkova; L P Nazarenko; N V Shilova; A R Shorina; I N Lebedev; O L Serov

doi:10.1016/j.scr.2018.101377

Induced pluripotent stem cell line, ICAGi001-A, derived from human skin fibroblasts of a patient with 2p25.3 deletion and 2p25.3-p23.3 inverted duplication

Stem Cell Res. 2019 Jan:34:101377. doi: 10.1016/j.scr.2018.101377. Epub 2018 Dec 18.

Authors

Affiliations

¹ Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia. Electronic address: anya.khabarova@gmail.com.
² Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia.
³ Research Institute of Medical Genetics, Tomsk NRMC, Tomsk, Russia.
⁴ Institute of Chemical Biology and Fundamental Medicine, SB RAS, Novosibirsk, Russia; Group of companies "Center of new medical technologies", Novosibirsk, Russia.
⁵ Research Centre for Medical Genetics, Moscow, Russia.
⁶ Clinical City Hospital №1, Novosibirsk, Russia.

PMID: 30616144
DOI: 10.1016/j.scr.2018.101377

Abstract

Skin fibroblasts from a patient with developmental delay and chromosome 2p25.3 deletion syndrome were reprogrammed into induced pluripotent stem cells (iPSCs) and the clonal stem cell line ICAGi001-A (iTAF9-11) was established. ICAGi001-A pluripotency was demonstrated in vitro by three germ layer differentiation capacity. This line is a good model for studying of the developmental delay and brain disorder.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Line
Child, Preschool
Chromosome Deletion*
Chromosome Disorders / genetics*
Chromosomes, Human, Pair 2 / genetics*
Female
Fibroblasts / pathology*
Humans
Induced Pluripotent Stem Cells / pathology*
Skin / pathology*