IL-17A-Producing γδT Cells Inhibit the Formation of Malignant Pleural Effusions

Am J Respir Cell Mol Biol. 2019 Aug;61(2):174-184. doi: 10.1165/rcmb.2018-0201OC.

Abstract

γδT cells are an important source of IL-17A and play an anti- or protumor role depending on the surrounding microenvironment. The precise role of γδT cells in the development of malignant pleural effusions (MPE) remains unknown. Using flow cytometry, we analyzed the distribution and differentiation of γδT cells in wild-type (WT) and IL-10-∕- mice. We carefully elucidated the influence of γδT cells on the formation of MPE by depleting γδT cells from WT, IL-10-∕-, and IL-17a-∕- mice. The distribution of γδT17 cells in human MPE and peripheral blood was also determined. Our data showed that both γδT cells and IL-17A-producing γδT (γδT17) cells accumulated in murine MPE, and IL-10 deficiency enhanced their accumulation. γδT cells were the main source of IL-17A in MPE for both WT and IL-10-∕- mice. IL-10 inhibited the chemotactic response of γδT cells to MPE and the proliferation of these cells. IL-10 suppressed γδT cell secretion of IL-17A via RORγt. The ablation of γδT cells accelerated MPE accumulation in both WT and IL-10-∕- mice, but it did not influence MPE accumulation in IL-17a-∕- mice. Patients with higher frequencies of γδT17 cells had significantly longer survival times than patients with lower frequencies of γδT17 cells. Taken together, our data demonstrate that γδT17 cells play an inhibitory role in the progression of MPE, and the accumulation of γδT17 cells in MPE is suppressed by IL-10.

Keywords: IL-10; IL-17A; malignant pleural effusion; γδT cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Differentiation
  • Cell Separation
  • Cell Survival
  • Chemotaxis
  • Flow Cytometry
  • Humans
  • Interleukin-10 / metabolism
  • Interleukin-17 / metabolism*
  • Intraepithelial Lymphocytes / cytology*
  • Leukocytes, Mononuclear / cytology
  • Lung Neoplasms / blood
  • Lung Neoplasms / metabolism
  • Major Histocompatibility Complex
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Microscopy, Fluorescence
  • Pleural Effusion, Malignant / metabolism*
  • Pleural Effusion, Malignant / pathology
  • Th17 Cells / pathology
  • Tumor Microenvironment

Substances

  • IL10 protein, human
  • IL10 protein, mouse
  • IL17A protein, human
  • Il17a protein, mouse
  • Interleukin-17
  • Interleukin-10