Transition Metal-Free Intermolecular C(sp2)-H Direct Amination of Furanones via a Redox Pathway

J Org Chem. 2019 Feb 1;84(3):1310-1319. doi: 10.1021/acs.joc.8b02760. Epub 2019 Jan 15.

Abstract

A direct C(sp2)-H amination of 2-furanones under metal-free conditions was realized. This unprecedented intermolecular C-H to C-N conversion provides rapid access to 4-amino-furanone derivatives and novel aza-heterocycle fused furanone skeletons. A redox mechanism based on a double-Michael-addition intermediate INT2 is proposed and detected by spectrometry.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amination
  • Catalysis
  • Furans / chemistry*
  • Oxidation-Reduction
  • Transition Elements / chemistry*

Substances

  • Furans
  • Transition Elements