The Antitumor Efficacy of a Complex Based on Two-Vector System for Coexpression of the Suicide Gene Fcu1 and Cre Recombinase

Dokl Biochem Biophys. 2018 Nov;483(1):326-328. doi: 10.1134/S1607672918060091. Epub 2019 Jan 3.

Abstract

In this study, we evaluated the antitumor activity of a gene therapy complex in which the tumor-specific control of the expression of the effector suicide gene FCU1 was performed using a two-vector system based on the site-specific Cre-LoxP recombinase system. The complex of interest showed a high therapeutic potential in a mouse colon adenocarcinoma model.

MeSH terms

  • Adenocarcinoma* / genetics
  • Adenocarcinoma* / metabolism
  • Adenocarcinoma* / therapy
  • Animals
  • Cell Line, Tumor
  • Colonic Neoplasms* / genetics
  • Colonic Neoplasms* / metabolism
  • Colonic Neoplasms* / therapy
  • Genes, Transgenic, Suicide*
  • Genetic Vectors* / genetics
  • Genetic Vectors* / metabolism
  • Integrases* / genetics
  • Integrases* / metabolism
  • Mice, Inbred BALB C
  • Neoplasms, Experimental* / genetics
  • Neoplasms, Experimental* / metabolism
  • Neoplasms, Experimental* / therapy

Substances

  • Cre recombinase
  • Integrases