Association of JAK2-V617F Mutations Detected by Solid Tumor Sequencing With Coexistent Myeloproliferative Neoplasms

JAMA Oncol. 2019 Feb 1;5(2):265-267. doi: 10.1001/jamaoncol.2018.6286.

Abstract

This study uses clinical sequencing data to examine the association between JAK2-V617F detected by solid tumor sequencing and mutations in the tumor, clonal hematopoiesis of indeterminate potential, or myeloproliferative neoplasms.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Biomarkers, Tumor / genetics*
  • DNA Mutational Analysis*
  • Female
  • Genetic Predisposition to Disease
  • Humans
  • Janus Kinase 2 / genetics*
  • Male
  • Middle Aged
  • Mutation*
  • Myeloproliferative Disorders / enzymology
  • Myeloproliferative Disorders / genetics*
  • Neoplasms / enzymology
  • Neoplasms / genetics*
  • Phenotype

Substances

  • Biomarkers, Tumor
  • JAK2 protein, human
  • Janus Kinase 2