Methemoglobinemia as a biomarker of dapsone-induced mania severity

Romain Colle; Abd El Kader Ait Tayeb; Pierre Mesdom; Mathilde de Menthon; Laurent Becquemont; Céline Verstuyft; Denis J David; Olivier Lambotte; Emmanuelle Corruble

doi:10.1016/j.jad.2018.12.123

Methemoglobinemia as a biomarker of dapsone-induced mania severity

J Affect Disord. 2019 Jul 1:254:122-123. doi: 10.1016/j.jad.2018.12.123. Epub 2018 Dec 25.

Authors

Romain Colle¹, Abd El Kader Ait Tayeb², Pierre Mesdom³, Mathilde de Menthon⁴, Laurent Becquemont⁵, Céline Verstuyft⁵, Denis J David⁶, Olivier Lambotte⁴, Emmanuelle Corruble²

Affiliations

¹ Service Hospitalo-Universitaire de Psychiatrie de Bicêtre, Hôpitaux Universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris, Hôpital de Bicêtre, Le Kremlin Bicêtre, F-94275, France; INSERM UMR-1178, CESP, "Depression and Antidepressants" team, Faculté de Médecine Paris-Sud, Université Paris Sud, France. Electronic address: romain.colle@aphp.fr.
² Service Hospitalo-Universitaire de Psychiatrie de Bicêtre, Hôpitaux Universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris, Hôpital de Bicêtre, Le Kremlin Bicêtre, F-94275, France; INSERM UMR-1178, CESP, "Depression and Antidepressants" team, Faculté de Médecine Paris-Sud, Université Paris Sud, France.
³ INSERM UMR-1178, CESP, "Depression and Antidepressants" team, Faculté de Médecine Paris-Sud, Université Paris Sud, France.
⁴ Service de Médecine Interne et Immunologie Clinique, Hôpitaux Universitaires Paris-Sud, Hôpital de Bicêtre, Le Kremlin Bicêtre, F-94275, France.
⁵ INSERM UMR-1178, CESP, "Depression and Antidepressants" team, Faculté de Médecine Paris-Sud, Université Paris Sud, France; Service de Génétique moléculaire, Pharmacogénétique et Hormonologie, Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Hôpital de Bicêtre, Le Kremlin Bicêtre, F-94275, France.
⁶ INSERM UMR-1178, CESP, "Depression and Antidepressants" team, Faculté de Pharmacie de Chatenay-Malabry, Université Paris Sud, France.

PMID: 30598189
DOI: 10.1016/j.jad.2018.12.123

Abstract

Background: The underlying mechanism involved in dapsone-induced mania remains unknown.

Methods: We report the case of a 54-year-old man with a dapsone-induced mania.

Results: The maximum of manic symptoms was correlated with the maximum of methemoglobinemia and mania decreased concomitantly with the methemoglobinemia level.

Limitations: This is a single case.

Conclusions: This case shows that dapsone-induced mania severity is correlated with methemoglobinemia level, leading for the first time to the hypothesis of a physiopathological mechanism by which dapsone could induce mania.

Keywords: Biomarker; Dapsone; Mania; Methemoglobinemia; Oxydative stress.

Publication types

Case Reports
Letter

MeSH terms

Biomarkers
Bipolar Disorder / chemically induced*
Dapsone / adverse effects*
Humans
Male
Methemoglobinemia / blood*
Middle Aged

Substances

Biomarkers
Dapsone