Modeling Peripartum Cardiomyopathy With Human Induced Pluripotent Stem Cells Reveals Distinctive Abnormal Function of Cardiomyocytes

Nili Naftali-Shani; Natali Molotski; Yael Nevo-Caspi; Michael Arad; Rafael Kuperstein; Uri Amit; Irit Huber; Li-At Zeltzer; Alina Levich; Haya Abbas; Lorenzo Monserrat; Gideon Paret; Jonathan Leor

doi:10.1161/CIRCULATIONAHA.118.035950

Modeling Peripartum Cardiomyopathy With Human Induced Pluripotent Stem Cells Reveals Distinctive Abnormal Function of Cardiomyocytes

Circulation. 2018 Dec 4;138(23):2721-2723. doi: 10.1161/CIRCULATIONAHA.118.035950.

Authors

Nili Naftali-Shani^{1

2}, Natali Molotski^{1

2}, Yael Nevo-Caspi³, Michael Arad^{4

5}, Rafael Kuperstein^{4

5}, Uri Amit^{1

2}, Irit Huber⁶, Li-At Zeltzer^{1

2}, Alina Levich^{1

2}, Haya Abbas³, Lorenzo Monserrat⁷, Gideon Paret³, Jonathan Leor^{1

4

2

5}

Affiliations

¹ Neufeld Cardiac Research Institute (N.N.-S., N.M., U.A., L.-a.Z, A.L., J.L.), Tel-Aviv University, Israel.
² Tamman Cardiovascular Research Institute (N.N.-S., N.M., U.A., L.-a.Z, A.L., J.L.), Leviev Heart Center, Sheba Medical Center, Tel-Hashomer, Israel.
³ Department of Pediatric Critical Care Medicine, Safra Children's Hospital, Tel-Hashomer, Israel (Y.N.-C., H.A., G.P.).
⁴ SacklerSchool of Medicine (M.A., R.K., J.L.), Tel-Aviv University, Israel.
⁵ Department of Cardiology (M.A., R.K., J.L.), Leviev Heart Center, Sheba Medical Center, Tel-Hashomer, Israel.
⁶ The Sohnis Family Laboratory for Cardiac Electrophysiology and Regenerative Medicine, Rappaport Faculty of Medicine, Technion-Institute of Technology, Haifa, Israel (I.H.).
⁷ Cardiology Department, Health in Code, A Coruña, Spain (L.M.).

PMID: 30571272
DOI: 10.1161/CIRCULATIONAHA.118.035950

No abstract available

Keywords: STAT3; cardiomyopathies; induced pluripotent stem cells; inflammation; neovascularization, physiologic; vascular endothelial growth factors.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Cardiomyopathies / metabolism
Cardiomyopathies / pathology*
Case-Control Studies
Cell Differentiation
Female
Humans
Induced Pluripotent Stem Cells / cytology
Induced Pluripotent Stem Cells / metabolism
Myocytes, Cardiac / cytology
Myocytes, Cardiac / metabolism*
Peripartum Period
STAT3 Transcription Factor / metabolism
Vascular Endothelial Growth Factor A / metabolism

Substances

STAT3 Transcription Factor
STAT3 protein, human
Vascular Endothelial Growth Factor A