Abstract
A NIR photosensitizer pyrrolopyrrole aza-BODIPY (PPAB) was synthesized in a straightforward manner. Through the use of PPAB NPs as a photothermal agent, photoacoustic imaging (PAI) and NIR fluorescence imaging (NIR-FI) can be achieved in vivo. In addition, the photothermal ablation of tumor cells can be realized both in vitro and in vivo, even at a low concentration (0.5 mg kg-1).
MeSH terms
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Animals
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Boron Compounds / chemistry*
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HeLa Cells
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Humans
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Infrared Rays
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Mice
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Microscopy, Confocal
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Neoplasms / drug therapy
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Neoplasms / pathology
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Neoplasms / therapy*
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Optical Imaging
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Photoacoustic Techniques
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Photosensitizing Agents / chemical synthesis
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Photosensitizing Agents / chemistry*
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Photosensitizing Agents / therapeutic use
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Phototherapy
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Pyrroles / chemistry*
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Transplantation, Heterologous
Substances
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Boron Compounds
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Photosensitizing Agents
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Pyrroles
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azaBDPBA compound