An acid-promoted cascade reaction of 4-chloroquinolin-3-yl carbamates with amines is described. This method achieves the formation of two new C-N bonds through an intermolecular amination/intramolecular cyclization reaction sequence. In combination with subsequent Suzuki coupling, this three-component telescopic procedure provides rapid access to various bioactive imidazo[4,5-c]quinolin-2-one derivatives.
Keywords: Acid-promoted reactions; Cyclization; Imidazo[4,5-c]quinolin-2-ones; Multicomponent reactions; One-pot synthesis.