Association between telomere length and cognitive ability in a community-based sample

Rishika Kaja; Stephanie M Reyes; Heidi C Rossetti; E Sherwood Brown

doi:10.1016/j.neurobiolaging.2018.11.006

Association between telomere length and cognitive ability in a community-based sample

Neurobiol Aging. 2019 Mar:75:51-53. doi: 10.1016/j.neurobiolaging.2018.11.006. Epub 2018 Nov 20.

Authors

Rishika Kaja¹, Stephanie M Reyes¹, Heidi C Rossetti¹, E Sherwood Brown²

Affiliations

¹ Department of Psychiatry, University of Texas Southwestern Medical Center of Dallas, Dallas, TX, USA.
² Department of Psychiatry, University of Texas Southwestern Medical Center of Dallas, Dallas, TX, USA. Electronic address: sherwood.brown@utsouthwestern.edu.

PMID: 30544048
DOI: 10.1016/j.neurobiolaging.2018.11.006

Abstract

Prior research suggests that telomere length is a biomarker of cognitive aging; however, literature has demonstrated conflicting findings to date. The present study uses data from the Dallas Heart Study, N = 2606, to assess the association between telomere length and cognitive ability on the Montreal Cognitive Assessment. The data do not support a relationship between telomere length and general cognitive functioning, (β = 0.016, SE = 0.31, p = 0.407). The data further replicate the negative findings within current literature.

Keywords: Cellular biomarker; Cognitive ability; Cognitive aging; Community-based sample; Telomere.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Aging / physiology*
Biomarkers / analysis*
Cognition / physiology*
Female
Humans
Male
Patient Compliance
Residence Characteristics
Telomere / metabolism*

Substances

Biomarkers