In recent years, the use of collagen cross-linking with ultraviolet A and riboflavin is being developed universally due to its significance in the improvement of the mechanical strength of collagen fibers in clinical and basic research. It has been used in treating some corneal diseases including keratoconus, keratectasia and keratohelcosis. Thus, it might become a new treatment to prevent progressive myopia by strengthening scleral tissue. This article focuses on the effectiveness and safety of ultraviolet A-riboflavin cross-linking, and discusses the application prospect, focal points and problems related to cross-linking therapy. (Chin J Ophthalmol, 2018, 54:948-953).
近年来紫外线A-核黄素胶原交联术在眼科的应用已较为普遍，临床及基础研究数据显示其可显著提高胶原纤维的机械强度，临床用于治疗圆锥角膜、角膜扩张性病变、角膜溃疡等疾病，而进一步的研究是利用其增强巩膜的生物力学强度，从而找到防控进行性近视眼的新方法。本文以紫外线A-核黄素角巩膜胶原交联术的有效性及安全性为重点，对角巩膜胶原交联术的应用前景、争论焦点以及应该注意的问题等进行阐述，以期为临床合理开展治疗提供参考。（中华眼科杂志，2018，54：948-953）.
Keywords: Collagen; Cornea; Cross-linking reagents; Riboflavin; Ultraviolet rays.