Variability of surgical prophylaxis in penicillin-allergic children

Infect Control Hosp Epidemiol. 2018 Dec;39(12):1480-1483. doi: 10.1017/ice.2018.244.

Abstract

We retrospectively evaluated the effect of penicillin adverse drug reaction (ADR) labeling on surgical antibiotic prophylaxis. Cefazolin was administered in 86% of penicillin ADR-negative (-) and 28% penicillin ADR-positive (+) cases. Broad-spectrum antibiotic use was more common in ADR(+) cases and was more commonly associated with perioperative adverse drug events.

MeSH terms

  • Adolescent
  • Anti-Bacterial Agents / adverse effects
  • Anti-Bacterial Agents / therapeutic use
  • Antibiotic Prophylaxis / methods*
  • Cefazolin / therapeutic use*
  • Child
  • Child, Preschool
  • Drug Hypersensitivity / epidemiology
  • Drug-Related Side Effects and Adverse Reactions / epidemiology
  • Electronic Health Records*
  • Female
  • General Surgery
  • Humans
  • Male
  • Pediatrics
  • Penicillins / adverse effects*
  • Preoperative Care / methods*
  • Retrospective Studies
  • Washington / epidemiology

Substances

  • Anti-Bacterial Agents
  • Penicillins
  • Cefazolin