Transvaginal fast-scanning optical-resolution photoacoustic endoscopy

Yuan Qu; Chiye Li; Junhui Shi; Ruimin Chen; Song Xu; Hasan Rafsanjani; Konstantin Maslov; Hannah Krigman; Laura Garvey; Peng Hu; Peinan Zhao; Karen Meyers; Emily Diveley; Stephanie Pizzella; Lisa Muench; Nina Punyamurthy; Naomi Goldstein; Oji Onwumere; Mariana Alisio; Kaytelyn Meyenburg; Jennifer Maynard; Kristi Helm; Janessia Slaughter; Sabrina Barber; Tracy Burger; Christine Kramer; Jessica Chubiz; Monica Anderson; Ronald McCarthy; Sarah K England; George A Macones; Qifa Zhou; K Kirk Shung; Jun Zou; Molly J Stout; Methodius Tuuli; Lihong V Wang

doi:10.1117/1.JBO.23.12.121617

Transvaginal fast-scanning optical-resolution photoacoustic endoscopy

J Biomed Opt. 2018 Dec;23(12):1-4. doi: 10.1117/1.JBO.23.12.121617.

Authors

Yuan Qu^{1

2}, Chiye Li^{1

2}, Junhui Shi³, Ruimin Chen⁴, Song Xu⁵, Hasan Rafsanjani⁵, Konstantin Maslov³, Hannah Krigman⁶, Laura Garvey⁶, Peng Hu^{1

2}, Peinan Zhao¹, Karen Meyers¹, Emily Diveley¹, Stephanie Pizzella¹, Lisa Muench¹, Nina Punyamurthy¹, Naomi Goldstein¹, Oji Onwumere¹, Mariana Alisio¹, Kaytelyn Meyenburg¹, Jennifer Maynard¹, Kristi Helm¹, Janessia Slaughter¹, Sabrina Barber¹, Tracy Burger¹, Christine Kramer¹, Jessica Chubiz¹, Monica Anderson¹, Ronald McCarthy¹, Sarah K England¹, George A Macones¹, Qifa Zhou⁴, K Kirk Shung⁴, Jun Zou⁵, Molly J Stout¹, Methodius Tuuli¹, Lihong V Wang³

Affiliations

¹ Washington University in St. Louis, March of Dimes Prematurity Research Center, Department of Obstet, United States.
² Washington University in St. Louis, Department of Biomedical Engineering, St. Louis, Missouri, United States.
³ California Institute of Technology, Caltech Optical Imaging Laboratory, Andrew and Peggy Cherng Depa, United States.
⁴ University of Southern California, NIH Ultrasonic Transducer Resource Center, Department of Biomedic, United States.
⁵ Texas A&M University, Department of Electrical and Computer Engineering, College Station, Texas, United States.
⁶ Washington University in St. Louis, Department of Pathology and Immunology, St. Louis, Missouri, United States.

Abstract

Photoacoustic endoscopy offers in vivo examination of the visceral tissue using endogenous contrast, but its typical B-scan rate is ∼10 Hz, restricted by the speed of the scanning unit and the laser pulse repetition rate. Here, we present a transvaginal fast-scanning optical-resolution photoacoustic endoscope with a 250-Hz B-scan rate over a 3-mm scanning range. Using this modality, we not only illustrated the morphological differences of vasculatures among the human ectocervix, uterine body, and sublingual mucosa but also showed the longitudinal and cross-sectional differences of cervical vasculatures in pregnant women. This technology is promising for screening the visceral pathological changes associated with angiogenesis.

Keywords: cervical imaging; fast scanning; microelectromechanical system scanning mirror; optical-resolution photoacoustic endoscopy.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Cervix Uteri / diagnostic imaging
Endoscopy / instrumentation*
Equipment Design
Female
Humans
Photoacoustic Techniques* / instrumentation
Photoacoustic Techniques* / methods
Pregnancy
Young Adult

Abstract

Publication types

MeSH terms

Grants and funding