First report of hepatobiliary Mycobacterium avium infection developing obstructive jaundice in a patient with neutralizing anti-interferon-gamma autoantibodies

H Namkoong; T Asakura; M Ishii; S Yoda; K Masaki; T Sakagami; E Iwasaki; Y Yamagishi; T Kanai; T Betsuyaku; N Hasegawa

doi:10.1016/j.nmni.2018.10.001

First report of hepatobiliary Mycobacterium avium infection developing obstructive jaundice in a patient with neutralizing anti-interferon-gamma autoantibodies

New Microbes New Infect. 2018 Oct 19:27:4-6. doi: 10.1016/j.nmni.2018.10.001. eCollection 2019 Jan.

Authors

H Namkoong^{1

2}, T Asakura¹, M Ishii¹, S Yoda³, K Masaki¹, T Sakagami⁴, E Iwasaki¹, Y Yamagishi¹, T Kanai¹, T Betsuyaku¹, N Hasegawa¹

Affiliations

¹ Keio University School of Medicine, Tokyo, Japan.
² Eiju General Hospital, Tokyo, Japan.
³ JCHO Saitama Medical Center, Saitama, Japan.
⁴ Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

Abstract

This study describes a patient who experienced hepatobiliary Mycobacterium avium infection associated with neutralizing anti-interferon gamma (IFN-γ) autoantibodies during treatment for disseminated M. avium disease. Hepatobiliary M. avium infection should be considered in jaundiced patients with neutralizing anti-IFN-γ autoantibodies, including those receiving antimycobacterial therapy for disseminated M. avium disease.

Keywords: Anti–interferon gamma (IFN-γ) autoantibody; Mycobacterium aviumcomplex (MAC); disseminated Mycobacterium aviumcomplex infection; hepatobiliary infection; jaundice.

Publication types

Case Reports