Antitumoral activity of quinoxaline derivatives: A systematic review

Eur J Med Chem. 2019 Feb 1:163:136-147. doi: 10.1016/j.ejmech.2018.11.059. Epub 2018 Nov 24.

Abstract

Cancer is a leading cause of death and a major health problem worldwide. While many effective anticancer agents are available, the majority of drugs currently on the market are not specific, raising issues like the common side effects of chemotherapy. However, recent research hold promise for the development of more efficient and safer anticancer drugs. Quinoxaline and its derivatives are becoming recognized as a novel class of chemotherapeutic agents with activity against different tumors. The present review compiles and discusses studies concerning the therapeutic potential of the anticancer activity of quinoxaline derivatives, covering articles published between July 2013 and July 2018.

Keywords: Anticancer; Biological applications; Chemistry; Kinase inhibitors; Quinoxaline; SAR.

Publication types

  • Systematic Review

MeSH terms

  • Antineoplastic Agents / pharmacology*
  • Humans
  • Neoplasms / drug therapy*
  • Quinoxalines / pharmacology
  • Quinoxalines / therapeutic use*

Substances

  • Antineoplastic Agents
  • Quinoxalines