Pharmacological treatment of COPD - New evidence

Pulmonology. 2019 Mar-Apr;25(2):90-96. doi: 10.1016/j.pulmoe.2018.10.005. Epub 2018 Nov 28.

Abstract

Chronic Obstructive Pulmonary Disease (COPD) is currently the 4th leading cause of death worldwide but is projected to be the 3rd leading cause of death by 2020. In Portugal, the estimated prevalence of COPD in the Lisbon region is 14.2%, and a large proportion of underdiagnosed disease has been detected. In 2016, a Portuguese panel of experts proposed pharmacological treatment approaches to COPD based on the evidence available at the time. However, given that the GOLD 2017 report introduced considerable changes to the 2016 version, and that new evidence has emerged regarding treatment options, these proposals need to be updated. Also, and based on several studies, the concept of Pre-GOLD patients, which has diagnostic, prognostic and therapeutic implications, is introduced, along with a proposed algorithm for the identification and treatment of these patients.

Keywords: Algorithm; Diagnosis; FLAME; Pre-GOLD patients.

Publication types

  • Review

MeSH terms

  • Administration, Inhalation
  • Algorithms
  • Bronchodilator Agents / therapeutic use
  • Disease Progression
  • Drug Combinations
  • Fluticasone-Salmeterol Drug Combination / administration & dosage
  • Fluticasone-Salmeterol Drug Combination / therapeutic use
  • Forced Expiratory Volume / drug effects*
  • Glycopyrrolate / administration & dosage
  • Glycopyrrolate / therapeutic use
  • Humans
  • Indans / administration & dosage
  • Indans / therapeutic use
  • Portugal / epidemiology
  • Prevalence
  • Prognosis
  • Pulmonary Disease, Chronic Obstructive / classification
  • Pulmonary Disease, Chronic Obstructive / drug therapy*
  • Pulmonary Disease, Chronic Obstructive / mortality*
  • Pulmonary Disease, Chronic Obstructive / physiopathology
  • Quinolones / administration & dosage
  • Quinolones / therapeutic use
  • Risk Factors
  • Severity of Illness Index

Substances

  • Bronchodilator Agents
  • Drug Combinations
  • Fluticasone-Salmeterol Drug Combination
  • Indans
  • Quinolones
  • indacaterol-glycopyrronium combination
  • Glycopyrrolate