Abstract
As a robust radioanalytical method for tracking carbonaceous particulates in vivo, polycyclic aromatic hydrocarbons from diesel exhaust were labeled with a radioactive-iodine-tagged pyrene analogue. Single-photon emission computed tomography and biodistribution studies showed high uptake and slow clearance of this matter in the respiratory system, which may underlie its severe toxicity.
MeSH terms
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Animals
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Iodine / chemistry
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Mice
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Polycyclic Aromatic Hydrocarbons / administration & dosage
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Polycyclic Aromatic Hydrocarbons / chemical synthesis
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Polycyclic Aromatic Hydrocarbons / pharmacokinetics*
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Pyrenes / chemistry
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Tissue Distribution
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Tomography, Emission-Computed, Single-Photon
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Vehicle Emissions*
Substances
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Polycyclic Aromatic Hydrocarbons
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Pyrenes
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Vehicle Emissions
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Iodine
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pyrene